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The article presents a comprehensive study on the potential of additive technologies in creating personalized therapeutic devices in dentistry. The development of additive manufacturing has significantly expanded the possibilities for individualizing preventive measures, allowing the creation of devices that correspond to the unique oral anatomy of each patient. A comparative analysis of the clinical effectiveness of supportive therapy using traditional methods versus individual 3D-printed devices was conducted. The study involved 120 patients aged 18-45 years, divided into two groups. The main group received treatment using personalized 3D-printed trays manufactured from digital impressions using SLA technology and biocompatible photopolymer materials. The control group underwent traditional preventive procedures. Clinical indicators, evaluated using OHI-S, PMA, PBI indices and TER test during a 6-month observation period, demonstrated a statistically significant advantage of the individualized approach. In the main group, a decrease in the OHI-S index by 61.1 % versus 29.4 % in the control group, PMA index by 58.1 % versus 34.5 %, and PBI index by 66.7 % versus 46.2 % was recorded. Additionally, improvement in the mineralizing potential of oral fluid and a decrease in TER test indicators by 52.9 % versus 26.9 % in the control group was observed. The fabrication protocol included acquiring digital impressions using an intraoral scanner (Medit i500), computer modeling with specialized dental CAD software (Exocad DentalCAD), and manufacturing using an SLA printer (Form 3B) with biocompatible photopolymer material (Dental LT Clear Resin). Digital workflow analysis demonstrated that this approach reduced production time by approximately 45 % compared to conventional methods while eliminating material waste and impression deformation issues. Physical-mechanical testing revealed optimal properties with tensile strength of 65.7±4.2 MPa, Shore D hardness of 83.5±2.1, elasticity modulus of 2850±185 MPa, and water absorption of only 0.23±0.04 %, which ensures dimensional stability in the moist oral environment. The accuracy analysis revealed a pattern where precision gradually decreased from anterior (0.07±0.01 mm deviation) to posterior regions (0.11±0.03 mm for molars), though all values remained within clinically acceptable limits. Patient-reported outcomes showed significantly higher comfort ratings for customized devices (8.7±0.9 vs. 6.3±1.2 on VAS, p<0.001) and substantially better compliance (92.5±5.4 % vs. 78.2±8.7 %, p<0.01) compared to standard appliances. Side effects were observed in only 4.8 % of patients using personalized devices compared to 18.2 % in the control group, with a significantly higher proportion of patients willing to continue using customized devices after study completion (95.2 % vs. 75.8 %, p<0.05). The findings from this interdisciplinary investigation, combining materials science, digital dentistry, and clinical assessment, confirm that 3D printing technology enables the creation of high-precision individual supportive therapy devices that demonstrate significantly higher clinical efficacy and patient acceptance compared to standardized approaches, suggesting this technology represents a significant advancement in preventive dentistry by enabling truly personalized oral health interventions tailored to individual patient needs.