Primary Pulmonary Epithelioid Angiosarcoma With Partial Response to Paclitaxel Treatment: A Case Report

Pulmonary epithelioid angiosarcoma is a rare, highly aggressive malignancy for which established treatment protocols are lacking. Here, we report the case of a 73-year-old male diagnosed with primary pulmonary epithelioid angiosarcoma with multiple metastases. While paclitaxel is effective for angiosarcoma, its use in pulmonary epithelioid angiosarcoma, to our knowledge, has not been previously reported. Surgery and radiotherapy were not feasible in this patient due to the advanced disease stage. Although disease progression ultimately occurred, weekly paclitaxel monotherapy achieved a clinically meaningful partial response. This case highlights that paclitaxel monotherapy selected based on the patient's overall condition can be a rational therapeutic choice to achieve objective tumor control in frail patients, serving as a valuable benchmark for individualized treatment selection in the absence of a standard treatment.