Relative Impact of GLP-1 Agonist Use on Microvascular Versus Macrovascular Complications

The use of GLP-1 RAs was linked to increased odds of microvascular complications following adjustment for the confounders, even as no significant association was reported with macrovascular complications. This possibly reflects confounding through indication, given that such medications/agents are mainly prescribed to persons with either longer duration or increasingly severe diabetes. These findings indicate the need for longitudinal studies to explain the temporal correlations between the use of GLP-1 RA and complication risk.