Total Synthesis of Honokiol via Oxidative Phenol Coupling

Herein we disclose the total synthesis of honokiol in six steps in an overall yield of 66%. Two distinct routes were explored, with the key steps being highly efficient and selective cross-couplings of commercially available phenols to construct the main biphenolic backbone. The routes employ inexpensive reagents and are scalable, high-yielding processes. The experimental procedures are reported in the conventional narrative format and two machine-readable formats.