Nd:YAG Laser Induced Microfragmentation in Intraocular Lenses: A Correlative Optical and Raman Spectroscopy Study

This study demonstrates that solid IOL-derived fragments can be released by standard laser energy levels used in posterior capsulotomy. Although conducted <i>in vitro</i>, the findings raise concerns about the potential clinical relevance of laser-induced material release. Free-floating debris may contribute to straylight, glare, increased intraocular pressure, or inflammatory responses. Further clinical studies are warranted to systematically assess whether such microfragments lead to postoperative complications. Optimized laser parameters and precise focusing are recommended to minimize structural damage and fragment release.