Reported associations between kratom and seizures: a systematic review

Currently, the available literature primarily consists of a limited number of studies, including case reports and case series, which document self-reported kratom use and provide minimal quantitative toxicological data on mitragynine. Based on our narrative review, we conclude that there is insufficient evidence to suggest that kratom causes seizures, primarily due to the absence of a quantitative dose-response in toxicology reports, a incomplete medical records and because seizures occur relatively frequently in the general population.