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The global food crises and growing population necessitate efficient agricultural land use. Weeds cause up to 40% yield loss in major crops, resulting in over USD 100 billion in annual economic losses. Camera-equipped UAVs offer a solution for automatic weed detection, but the high computational and energy demands of deep learning models limit their use to expensive, high-end UAVs. In this paper, we present a low-cost UAV system built from off-the-shelf components, featuring a custom-designed on-board computing system based on the NVIDIA Jetson Nano. This system efficiently manages real-time image acquisition and inference using the energy-efficient Squeeze U-Net neural network for weed detection. Our approach ensures the pipeline operates in real time without affecting the drone’s flight autonomy. We also introduce the AgriAdapt dataset, a novel collection of 643 high-resolution aerial images of salad crops with weeds, which fills a key gap by providing realistic UAV data for benchmarking segmentation models under field conditions. Several deep learning models are trained and validated on the newly introduced AgriAdapt dataset, demonstrating its suitability for effective weed segmentation in UAV imagery. Quantitative results show that the dataset supports a range of architectures, from larger models such as DeepLabV3 to smaller, lightweight networks like Squeeze U-Net (with only 2.5 M parameters), achieving high accuracy (around 90%) across the board. These contributions distinguish our work from earlier UAV-based weed detection systems by combining a novel dataset with a comprehensive evaluation of accuracy, latency, and energy efficiency, thus directly targeting deep learning applications for real-time UAV deployment. Our results demonstrate the feasibility of deploying a low-cost, energy-efficient UAV system for real-time weed detection, making advanced agricultural technology more accessible and practical for widespread use.