Temporal Trends in Mortality Related to Pancreatic Cancer and Cachexia in the United States

Mortality from pancreatic cancer with cachexia as a contributing cause has declined over two decades, though sex-, race-, and geography-based disparities persist. Interpretation should consider data suppression for small subgroups and potential misclassification or underreporting of cachexia on death certificates. Continued efforts to improve coding accuracy, nutritional assessment, and palliative care integration are vital to reducing inequities and improving patient outcomes.