Effects of Continuous Oral Intake of DR.ERGO ^® Ergothioneine Capsules on Skin Status: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract Background Ergothioneine (ergothioneine) is a naturally occurring antioxidant with emerging evidence supporting its role in cellular protection and anti-aging. However, clinical data on its cosmetic benefits remain limited. Objective To evaluate the effects of daily oral supplementation with DR.ERGO ® ergothioneine capsules on skin condition in healthy women reporting signs of skin aging. Methods In this 8-week, randomized, double-blind, placebo-controlled trial, 66 women aged 35–59 years were assigned to receive either DR.ERGO ® ergothioneine (30 mg/day) or placebo. Skin parameters including melanin index, erythema index, glossiness, elasticity (R2, R5, R7), spot count, wrinkle count were evaluated at baseline, 4 weeks, and 8 weeks. Results Compared to placebo, the DR.ERGO ® ergothioneine group showed significantly greater improvements in melanin and erythema reduction, skin glossiness, elasticity, and wrinkle and spot reduction (all p < 0.01). No adverse events were reported. Conclusion Continuous oral intake of DR.ERGO ® ergothioneine significantly improved skin aging parameters, with excellent safety and tolerability. These findings suggest DR.ERGO ® ergothioneine may serve as an effective oral anti-aging agent.