Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study

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Authors

B Ruan · Cornell University

Sarojini Bulbule · University of Wisconsin–Milwaukee

Brooke Gile · University of Wisconsin–Milwaukee

Amy Reyes · University of Wisconsin–Milwaukee

Bela Chheda · Palo Alto Research Center

Lucinda Bateman · Bateman Horne Center

Jennifer Bell ·

Abstract

Low-dose rapamycin effectively reduced PEM and other key symptoms in patients with ME/CFS, as measured by BAS, SSS, MFI, and SF-36. Future studies should encompass dose optimization and develop a diagnostic tool to identify responders with mTOR-mediated autophagy disruption.

Topics & Keywords

Fibromyalgia and Chronic Fatigue Syndrome Research Autophagy in Disease and Therapy Parkinson's Disease Mechanisms and Treatments

Publication Details

Published in: Journal of Translational Medicine

Volume 23, Issue 1, pp. 1148-1148

DOI: 10.1186/s12967-025-07213-8

Field-Weighted Citation Impact: 4.52

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Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study

Authors

Abstract

Topics & Keywords

Publication Details