MON-016 Hypersexuality With the Use of Serotonin Receptor Inhibitors in Perimenopausal Women

Abstract Disclosure: C. Dominguez-Bali: None. E. Johnson: None. R. Polam: None. H.A. Goraya: None. M.A. Syed: None. W. Massah: None. E.S. Tsehaye: None. K. MCcoy: None. M.A. Bencomo: None. A. Dominguez-Bali: None. Hypersexuality With the Use of Selective Serotonin Receptor Inhibitors in Perimenopausal Women This report presents two cases of hypersexuality in perimenopausal women who were using Bupropion and Fluoxetine, a phenomenon rarely documented in medical literature, with only one prior case reported. The aim of this presentation is to explore a potential link between the use of SSRI medications (specifically Bupropion and Fluoxetine) and the onset of hypersexual behavior in perimenopausal women. An analysis was conducted on two cases involving a newly described sexual dysfunction potentially related to SSRI use. Patients were prescribed Bupropion (150 mg orally, twice daily) and Fluoxetine (125 mg orally, once daily).In the first case, one week after initiating Fluoxetine, while already on Bupropion for months, the patient developed a heightened and uncontrollable need for sexual activity. Often engaging with multiple partners, including the participation of sexual activities with her husband and others. Despite her efforts to maintain her marriage, her compulsive behavior eventually led to marital separation. The second patient, also on Bupropion and Fluoxetine, exhibited hypersexual behavior shortly after starting Fluoxetine, engaging in multiple extramarital relationships. Both cases displayed a temporal link between Fluoxetine initiation and hypersexuality onset.Discontinuation of both medications led to the cessation of compulsive sexual behaviors in both patients, suggesting a possible association between these SSRIs and hypersexuality in perimenopausal women. Presentation: Monday, July 14, 2025