MON-602 Role of Omnipod 5 Automated Insulin Infusion on Glucose Management in Patient with Anti-Insulin Antibodies

Abstract Disclosure: E. Mendez: None. N. Habo: None. Y. Habo: None. M.I. Castillo: None. P. Maza Hill: None. P. Wuilleumier Cerra: None. A. Habouh: None. N.H. Shaaban: None. Background: Insulin autoimmune syndrome is a rare disorder characterized by anti-insulin antibodies which cause hyperinsulinemic hypoglycemia without any prior use of exogenous insulin. We report a case of a patient with anti-insulin antibodies and treatment with HumuLIN R U-200 insulin through Insulin Pump. Case Presentation: A 44-year-old female with past medical history of type 2 diabetes mellitus, hypertension, dyslipidemia, and obstructive sleep apnea presented to the clinic with persistent symptoms such as dizziness, blurry vision, polyuria, polydipsia, thirst, abdominal pain, numbness, and cramps in her legs. Previous management included metformin, Humalog 16 units before each meal, and Levemir 39 units at night. Symptoms persisted with this management and the patient's glucometer showed low levels as low as 180 mg/dL and high levels up to 450 mg/dL. Patient was also hospitalized earlier in the month for a level above 600 mg/dL. Significant family medical history included mother with type 2 diabetes mellitus and hypertension as well as father with type 2 diabetes mellitus. Discussion: The persistence of hyperglycemia and symptoms despite adherence to a standard diabetes management regimen suggests a potential underlying issue, such as insulin resistance or inadequate response to therapy. Conclusion: We believe this demonstrates successful management of the rare disorder of insulin autoimmune syndrome with the use of HumuLIN R U-200 insulin through Insulin Pump. Through multiple medication and treatment adjustments this patient’s case shows an improvement over the course of treatment that can be used for future tests and trials. Presentation: Monday, July 14, 2025