Lurking in Ambush: A Case Report of Probable Creutzfeldt-Jakob Disease From Rural Kerala, India

Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive neurodegenerative disorder caused by prion proteins. This case report describes a probable instance of sporadic CJD in an elderly male from rural Kerala, India. The patient presented with rapidly evolving neurocognitive decline, myoclonus, and characteristic MRI and EEG findings. Despite limited resources, a probable diagnosis was established through clinical evaluation and supportive investigations. This case highlights the challenges of diagnosing rare neurological disorders in resource-constrained settings and underscores the importance of clinical vigilance in rural healthcare practice.