Ambroxol is Effective for Corneal Pain in Rats

20250 citationsJournal Article

Authors

Ao-Ling Li · Tongji Hospital

Xuejiao Chang · Tongji Hospital

Qi Pu · Tongji Hospital

Xiaoxiao Guo · Tongji Hospital

Eugene M. Wang · University of Rochester

Guigang Li · Tongji Hospital

Mingwu Wang · University of Arizona

Abstract

Selective blockage of key nociceptors of the cornea by ambroxol is effective in suppressing corneal pain and heightened nociceptor excitability, leading to modulation of NCP. Sparing certain CS could translate into more protection to the ocular surface. No overt toxicity of ambroxol was seen in cultured human corneal epithelial cells in this study.

Topics & Keywords

Pain Mechanisms and Treatments Plant Toxicity and Pharmacological Properties Ocular Surface and Contact Lens

Publication Details

Published in: Journal of Ocular Pharmacology and Therapeutics

DOI: 10.1177/10807683251391936

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Ambroxol is Effective for Corneal Pain in Rats

Authors

Abstract

Topics & Keywords

Publication Details