Repertoire and clinical hierarchy of AR locus alterations in castration-resistant prostate cancer

20251 citationsJournal Articlehybrid Open Access

Authors

Tuomo Virtanen · Tampere University

Edmond M. Kwan · University of British Columbia

Kinnari Parekh · University of British Columbia

Jack V. W. Bacon · University of British Columbia

Chia-Chi Flora Huang · University of British Columbia

Ivan Pak Lok Yu · University of British Columbia

Lauri Ryyppö

Abstract

This study provides the most comprehensive resource to date characterizing somatic alterations at the AR locus. Our clinicogenomic analysis establishes the repertoire and clinical relevance of AR genotypes in mCRPC, informing efforts to target renewed AR dependency.

Topics & Keywords

Prostate Cancer Treatment and Research Cancer-related gene regulation Ubiquitin and proteasome pathways

Publication Details

Published in: Annals of Oncology

Volume 37, Issue 3, pp. 388-402

DOI: 10.1016/j.annonc.2025.10.1236

Field-Weighted Citation Impact: 1.52

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Repertoire and clinical hierarchy of AR locus alterations in castration-resistant prostate cancer

Authors

Abstract

Topics & Keywords

Publication Details