Indomethacin Fails to Increase Intestinal Permeability in Healthy Volunteers

20250 citationsJournal Articlegold Open Access

Authors

Michael Camilleri · Mayo Clinic in Florida

Irene Busciglio · Mayo Clinic

Paula Carlson · Mayo Clinic

Saam Dilmaghani · Mayo Clinic

Camille Lupianez‐Merly · Mayo Clinic

David Yi Yang · Mayo Clinic

Michael Ryks · Mayo Clinic in Florida

Abstract

Our findings suggest that the expected increase in intestinal permeability after indomethacin administration may not be consistently observed in healthy volunteers. These results highlight the need to carefully consider the reproducibility and sensitivity of this model in future clinical studies aiming to investigate gut barrier function.

Topics & Keywords

Barrier Structure and Function Studies Gut microbiota and health Drug Transport and Resistance Mechanisms

Publication Details

Published in: Clinical and Translational Gastroenterology

Volume 17, Issue 1, pp. e00944-e00944

DOI: 10.14309/ctg.0000000000000944

Field-Weighted Citation Impact: 0.00

Command Palette

Indomethacin Fails to Increase Intestinal Permeability in Healthy Volunteers

Authors

Abstract

Topics & Keywords

Publication Details