Synthesis of Rhodamine B Derivatives Doped Contact Lenses via Graft Copolymerization and their Application in Color Vision Correction

Color vision deficiency (CVD), particularly red‐green color blindness, significantly impairs color discrimination in daily life. Conventional colored lenses and filters often suffer from dye leakage and poor biocompatibility, limiting their clinical use. In this article, colorblind‐correcting contact lenses are developed by chemically grafting a Rhodamine B derivative onto 2‐hydroxyethyl methacrylate‐based polymer networks. This covalent immobilization prevents dye leaching and confers selective light absorption within the 540–570 nm spectral range, thereby specifically targeting red‐green CVD. Compared with physical doping, the chemically grafted lenses exhibit over 95% dye retention, maintained mechanical and optical integrity, and demonstrated excellent biocompatibility with >95% cell viability in L929 and human corneal epithelial cells assays. Simulated clinical tests using the Ishihara plates revealed up to an 85% improvement in recognition accuracy. This approach presents a safe, stable, and effective pathway toward wearable visual correction technologies.