Relationship between vitamin D deficiency and early implant failure and osseointegration

Evidence from both animal and human studies strongly indicates that vitamin D deficiency impairs both new bone formation and BIC. Supplementation, particularly in patients with systemic conditions, may improve implant osseointegration outcomes. Pre-operative screening and correction of vitamin D deficiency are recommended to optimize implant success. Additional well-designed prospective clinical trials and RCTs are needed to further elucidate the extent of the correlation between serum vitamin D deficiency and the risk of implant failure.