A qualitative burden of disease study in patients with invasive Escherichia coli disease aged ≥ 60 years in the United States

IED was shown to cause substantial physical, social, and psychological impacts in patients. This burden was especially apparent in review of patient self-reports for concepts that are part of generic HRQoL instruments (SF-36, EQ-5D), and patients also frequently reported neurological/mental impacts. Further, this study provides valuable qualitative data that may be useful for future research in developing a disease-specific instrument for the assessment of HRQoL in patients with IED.