Vascular Remodelling in COPD: An In Silico Tool to Represent Pulmonary Haemodynamics in Obstructive Lung Disease

20250 citationsJournal Articlehybrid Open Access

Authors

Behdad Shaarbaf Ebrahimi · University of Auckland

Merryn H. Tawhai · University of Auckland

Abstract

This model reproduces clinically measured mPAP and pulmonary vascular resistance values across COPD stages and quantifies how specific degrees of remodelling and pruning drive haemodynamic deterioration. This model provides a tool for hypothesis testing, patient stratification, and evaluation of potential targeted therapies in obstructive lung disease.

Topics & Keywords

Pulmonary Hypertension Research and Treatments Chronic Obstructive Pulmonary Disease (COPD) Research Respiratory Support and Mechanisms

Publication Details

Published in: Annals of Biomedical Engineering

Volume 54, Issue 1, pp. 13-28

DOI: 10.1007/s10439-025-03891-z

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Vascular Remodelling in COPD: An In Silico Tool to Represent Pulmonary Haemodynamics in Obstructive Lung Disease

Authors

Abstract

Topics & Keywords

Publication Details