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This chapter explores the ethical and regulatory dimensions of generative artificial intelligence (AI) security, examining how organizations can responsibly develop and deploy these powerful systems while addressing complex ethical challenges. It analyzes fundamental ethical considerations, including transparency in AI decision-making, the importance of explainable AI (XAI) for accountability, persistent issues of bias and fairness, and the challenges of establishing clear responsibility in AI-driven security decisions. The chapter examines emerging governance frameworks—from organizational ethics committees to structured approaches like NIST's AI Risk Management Framework (RMF) and ISO 42001 —that provide systematic methodologies for managing AI risks. It surveys the rapidly evolving regulatory landscape, contrasting the comprehensive approach of the European Unions (EU) AI Act with state-level initiatives in the United States, like California's transparency requirements and Colorado's government-focused regulations. The discussion highlights human-in-the-loop (HITL) systems as essential for maintaining accountability, while emphasizing the critical balance between innovation and security through interdisciplinary collaboration and public–private partnerships (PPPs). Throughout, the chapter underscores that effective AI governance requires both technical safeguards and ethical frameworks to ensure these systems benefit society while minimizing potential harms.