An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of total and free valproic acid in human serum and plasma

20250 citationsJournal Articlehybrid Open Access

Authors

Tobias Schierscher · Labormedizinische Zentrum Dr Risch (Switzerland)

Linda Salzmann · Labormedizinische Zentrum Dr Risch (Switzerland)

Neeraj Singh · Roche Pharma AG (Germany)

Sarah Fleischer · Roche Pharma AG (Germany)

Cora Schäfer · Labormedizinische Zentrum Dr Risch (Switzerland)

Julia Hoop · Labormedizinische Zentrum Dr Risch (Switzerland)

Friederike Bauland

Abstract

We present novel ID-LC-MS/MS-based cRMPs for total and free valproic acid in human serum and plasma which provides a traceable and reliable platform for the standardization of routine assays and evaluation of clinically relevant samples.

Topics & Keywords

Pharmacological Effects and Toxicity Studies Histone Deacetylase Inhibitors Research Hormonal and reproductive studies

Publication Details

Published in: Clinical Chemistry and Laboratory Medicine (CCLM)

DOI: 10.1515/cclm-2025-1053

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An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of total and free valproic acid in human serum and plasma

Authors

Abstract

Topics & Keywords

Publication Details