Targeting the ATM–TGS1–BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma

20250 citationsJournal Article

Authors

Changying Li · Chinese Academy of Medical Sciences & Peking Union Medical College

X.-M. Zhao · Chinese Academy of Medical Sciences & Peking Union Medical College

Xinyan Li · Chinese Academy of Medical Sciences & Peking Union Medical College

Chunyan Wang · Shandong Provincial QianFoShan Hospital

Zhenyu Huo · Chinese Academy of Medical Sciences & Peking Union Medical College

Xin Xu · Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

The ATM-TGS1-BRCA1 signaling axis is a critical regulator of DNA repair that can be targeted to overcome genotoxic therapy resistance, providing a promising therapeutic strategy that could transform pancreatic cancer treatment.

Topics & Keywords

DNA Repair Mechanisms PARP inhibition in cancer therapy Cancer therapeutics and mechanisms

Publication Details

Published in: Cancer Research

Volume 86, Issue 3, pp. 730-745

DOI: 10.1158/0008-5472.can-25-1435

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Targeting the ATM–TGS1–BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma

Authors

Abstract

Topics & Keywords

Publication Details