IL-5 signaling in asthmatic derived fibroblasts exacerbates airway remodeling through ECM dysregulation and apoptosis resistance

20251 citationsJournal Articlegold Open Access

Authors

Rola AbuJabal · University of Sharjah

Tasneem M. Alanta · University of Sharjah

Reem Sami Alhamidi · University of Sharjah

Alaa Muayad Altaie · University of Sharjah

Lina Sahnoon · University of Sharjah

Bushra Mdkhana · University of Sharjah

Bassam Mahboub ·

Abstract

IL-5 directly activates lung fibroblasts to drive airway remodelling in severe asthma through ECM deposition, MMP/TIMP imbalance, and pro-fibrotic cytokine secretion, positioning it as a dual mediator of inflammation and fibrosis with novel therapeutic potential.

Topics & Keywords

Asthma and respiratory diseases Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Inhalation and Respiratory Drug Delivery

Publication Details

Published in: Respiratory Research

Volume 26, Issue 1, pp. 307-307

DOI: 10.1186/s12931-025-03371-x

Field-Weighted Citation Impact: 1.22

Command Palette

IL-5 signaling in asthmatic derived fibroblasts exacerbates airway remodeling through ECM dysregulation and apoptosis resistance

Authors

Abstract

Topics & Keywords

Publication Details