Distinct strategies of epithelial cell barrier disruption by Leptospira interrogans isolated from human patients in Okinawa, Japan

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Authors

Tetsuya Kakita · University of the Ryukyus

Claudia Toma · University of the Ryukyus

Isabel Sebastián · University of the Ryukyus

Hunter Barbee · University of the Ryukyus

Tetsu Yamashiro · University of the Ryukyus

Abstract

Our findings suggest that the maintenance of epithelial barrier integrity requires both the afadin-F-actin and α-catenin-F-actin links, and that Oki53 and Oki65 employ distinct strategies to disrupt the AJ-F-actin link and, thus, the epithelial barrier.

Topics & Keywords

Leptospirosis research and findings Brucella: diagnosis, epidemiology, treatment Whipple's Disease and Interleukins

Publication Details

Published in: PLoS neglected tropical diseases

Volume 19, Issue 11, pp. e0013693-e0013693

DOI: 10.1371/journal.pntd.0013693

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Distinct strategies of epithelial cell barrier disruption by Leptospira interrogans isolated from human patients in Okinawa, Japan

Authors

Abstract

Topics & Keywords

Publication Details