Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors

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Authors

Sam Lockhart · Queen's University Belfast

Anuradhika Puri · Washington University in St. Louis

Yajie Zhao · MRC Epidemiology Unit

Vladimı́r Saudek · Wellcome/MRC Institute of Metabolic Science

Eugene J. Gardner · MRC Epidemiology Unit

Katherine A. Kentistou · MRC Epidemiology Unit

Brian Lam

Abstract

We identified novel genetic variants predisposing to atherosclerotic cardiovascular diseases that act independently of established cardiovascular risk factors. The observed phenotypic and functional heterogeneities between HTRA1 variants suggest that distinct biochemical mechanisms drive HTRA1-related vascular disease in the brain and heart.

Topics & Keywords

Cerebrovascular and genetic disorders Neurological disorders and treatments Migraine and Headache Studies

Publication Details

Published in: Circulation Genomic and Precision Medicine

Volume 18, Issue 6, pp. e005233-e005233

DOI: 10.1161/circgen.125.005233

Field-Weighted Citation Impact: 1.39

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Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors

Authors

Abstract

Topics & Keywords

Publication Details