Protocolized natriuresis-guided diuretic therapy in acute heart failure: a systematic review and meta-analysis

In this meta-analysis of patients with AHF, protocolized natriuresis-guided therapy was safe and associated with improved diuresis and natriuresis after 48 h, as well as a reduced risk of acute kidney injury. While the short-term safety and efficacy are promising, further large RCTs are needed to evaluate the effects on clinical endpoints in diverse healthcare settings and patients worldwide.