Invasive Pneumococcal Disease at Eight Children’s Hospitals in the United States, 2018–2023

PCV13 serotypes (especially 3, 19A and 19F) continue to account for 30% of IPD in US children 8-13 years after PCV13 was introduced. Vancomycin should still be included in empiric treatment of bacterial meningitis in children. The introduction of PCV20 for routine administration to infants could result in further reductions in IPD in children.