Altered Vascular and Angiogenic Transcripts in the Neurogenic Niche in Neuroinflammatory-Type Schizophrenia

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Authors

Hayley F. North · The University of Sydney

Jessica Fang Yan Lim · Schizophrenia Research Institute

Janice M. Fullerton · New South Wales Department of Health

Maree J. Webster · Stanley Medical Research Institute

Cynthia Shannon Weickert · The University of Sydney

Abstract

These findings reveal that changes in the BBB and angiogenesis are more severe in high-inflammation schizophrenia and appear to be linked to reduced neurogenesis in the SEZ. This study underscores the importance of inflammation in shaping vascular and neurogenic pathology in schizophrenia, offering potential pathways for future therapeutic exploration.

Topics & Keywords

Tryptophan and brain disorders Neuroinflammation and Neurodegeneration Mechanisms Neurogenesis and neuroplasticity mechanisms

Publication Details

Published in: Schizophrenia Bulletin

DOI: 10.1093/schbul/sbaf177

Field-Weighted Citation Impact: 1.17

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Altered Vascular and Angiogenic Transcripts in the Neurogenic Niche in Neuroinflammatory-Type Schizophrenia

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Abstract

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Publication Details