A Population Pharmacokinetic and Exposure–Response Analysis for Baricitinib in Pediatric Patients with Atopic Dermatitis

20250 citationsJournal Articlehybrid Open Access

Authors

Rodney L. Decker · Eli Lilly (United States)

C. Steven Ernest · Metrum Research Group (United States)

David B. Radtke · Eli Lilly (United States)

Apurva Prakash · Eli Lilly (United States)

Abstract

The population PK model developed using baricitinib concentrations from adult patients, with allometric scaling for weight on clearance and volume, adequately predicted exposures in the pediatric population. The PK modeling, with E-R analysis, informed an appropriate weight-based dosing regimen.

Topics & Keywords

Dermatology and Skin Diseases Inflammatory Bowel Disease Psoriasis: Treatment and Pathogenesis

Publication Details

Published in: Clinical Pharmacokinetics

Volume 65, Issue 1, pp. 119-131

DOI: 10.1007/s40262-025-01563-8

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A Population Pharmacokinetic and Exposure–Response Analysis for Baricitinib in Pediatric Patients with Atopic Dermatitis

Authors

Abstract

Topics & Keywords

Publication Details