What OPTIMISTmain Teaches About Margins, Imputation, and Interpretation

OPTIMISTmain was a clinical trial examining low-intensity post-thrombolysis monitoringcompared to standard monitoring in patients with acute ischemic stroke. This article examinesthe clinical trial’s data management, alongside the study’s statistical analysis plan, and reportedanalytical results offering stroke clinicians insight into non-inferiority trial interpretation andreadiness for practice implementation.