Mitochondrial Transfer Rescues Respiration to Support <i>De Novo</i> Pyrimidine Biosynthesis and Tumor Progression

20250 citationsJournal Articlehybrid Open Access

Authors

Maria Dubisova · Charles University

Klára Boháčová · Charles University

Zuzana Nahácka · Czech Academy of Sciences

Daniel Kraus · Charles University

Jaromı́r Novák · Charles University

Šárka Dvořáková · Czech Academy of Sciences, Institute of Biotechnology

Petra Brisudová ·

Abstract

Mitochondrial complexes III and IV promote tumor progression by supporting de novo pyrimidine synthesis, requiring cancer cells devoid of mitochondrial DNA to recruit mitochondria from source cells to restore respiration in order to form tumors.

Topics & Keywords

ATP Synthase and ATPases Research Mitochondrial Function and Pathology Biochemical and Molecular Research

Publication Details

Published in: Cancer Research

Volume 86, Issue 4, pp. 925-939

DOI: 10.1158/0008-5472.can-24-0737

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Mitochondrial Transfer Rescues Respiration to Support <i>De Novo</i> Pyrimidine Biosynthesis and Tumor Progression

Authors

Abstract

Topics & Keywords

Publication Details