Impact of DNA-stored mutations on virological response in virologically suppressed PWH in the switch to modern regimens

20250 citationsJournal Articlehybrid Open Access

Authors

Francesca Lombardi · Università Cattolica del Sacro Cuore

Elio Gentilini Cacciola · Sapienza University of Rome

Federica Carli · Ospedale di Parma

Francesco Saladini · University of Siena

Francesco Bassani · University of Milan

Ilaria Vicenti · University of Siena

William Gennari

Abstract

Our findings evidence the role of archived resistance in predicting VR after switch therapy in suppressed PWH. Thus, proviral GRT could be a useful tool to optimise strategies for switching treatment, especially if paired with information on previous historical resistance and the duration under suppression.

Topics & Keywords

Virus-based gene therapy research Polyomavirus and related diseases HIV/AIDS drug development and treatment

Publication Details

Published in: International Journal of Antimicrobial Agents

Volume 67, Issue 1, pp. 107670-107670

DOI: 10.1016/j.ijantimicag.2025.107670

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Impact of DNA-stored mutations on virological response in virologically suppressed PWH in the switch to modern regimens

Authors

Abstract

Topics & Keywords

Publication Details