Aphrodisiac Drug and Dental Health: A Systematic Review

Aphrodisiac drugs, including both synthetic agents such as sildenafil and herbal formulations like ginseng, are widely used for enhancing sexual function. Emerging evidence suggests these agents may also impact oral and periodontal health, though the relationship remains underexplored. To systematically evaluate the effects of aphrodisiac drugs on dental and oral health outcomes. This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was performed to identify studies from 2000 to 2025. Inclusion criteria encompassed original studies involving aphrodisiac drugs with reported oral health outcomes. Reviews, animal studies, in vitro research, and clinical trials were all considered. Ten studies met the eligibility criteria. Sildenafil was associated with reduced alveolar bone loss and inflammation in preclinical models. Ginsenosides demonstrated strong anti-inflammatory, antimicrobial, and osteogenic activity. One clinical trial found red ginseng mouth rinse comparable to chlorhexidine in plaque control. Overall, ginseng-derived compounds showed promise in managing periodontitis and maintaining oral health. Both synthetic and herbal aphrodisiac agents exhibit potential oral health benefits, especially in periodontal therapy. Further clinical research is essential to confirm their safety, efficacy, and applicability in dental care.