High <i>MDR1</i> expression in RA is associated with increased MMP-3 levels and use of bDMARDs: potential independence of JAK inhibitors from <i>MDR1</i>

20251 citationsJournal Article

Authors

Yuma Onoi · Kobe University

Shinya Hayashi · Kobe University

Kenichi Kikuchi · Kobe University

Masanori Tsubosaka · Kobe University

Tomoyuki Kamenaga · Kobe University

Yuichi Kuroda · Kobe University

Naoki Nakano · Kobe University

Abstract

High MDR1 expression correlates with elevated MMP-3 levels and more frequent bDMARDs use. JAK inhibitors remain effective regardless of MDR1 status, potentially bypassing MDR1-mediated cellular drug resistance in RA.

Topics & Keywords

Drug Transport and Resistance Mechanisms Myeloproliferative Neoplasms: Diagnosis and Treatment Protein Kinase Regulation and GTPase Signaling

Publication Details

Published in: Lara D. Veeken

Volume 65, Issue 2

DOI: 10.1093/rheumatology/keaf622

Field-Weighted Citation Impact: 1.19

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High <i>MDR1</i> expression in RA is associated with increased MMP-3 levels and use of bDMARDs: potential independence of JAK inhibitors from <i>MDR1</i>

Authors

Abstract

Topics & Keywords

Publication Details