Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia

20250 citationsJournal Articlegreen Open Access

Authors

Johanna Eriksson · University of Helsinki

Shuyu Zheng · University of Helsinki

Mihaela Popa · Uni Research (Norway)

Jie Bao · University of Helsinki

Jun Dai · University of Helsinki

Wenyu Wang · University of Helsinki

Emmet McCormack ·

Abstract

Single-cell lineage tracing with ReSisTrace reveals cellular states that prime treatment resistance and identifies approaches to sensitize FLT3-ITD-positive acute myeloid leukemia to FLT3 inhibitors.

Topics & Keywords

Acute Myeloid Leukemia Research PI3K/AKT/mTOR signaling in cancer Protein Degradation and Inhibitors

Publication Details

Published in: Cancer Research

Volume 86, Issue 7, pp. 1724-1738

DOI: 10.1158/0008-5472.can-24-3753

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Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia

Authors

Abstract

Topics & Keywords

Publication Details