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<bold>Aim:</bold> Most NHS patients self-administer their biologics treatment at home, creating a need to support remote monitoring of patients. This real-world evaluation assesses the value of a digital app designed to support severe asthma self-management and facilitate automated clinical data collection and upload to the National Severe Asthma Registry in NHS Severe Asthma Centres (SACs). The study explores adoption, usability, and potential clinical benefits while identifying barriers to implementation. <bold>Method:</bold> Health Innovation Oxford conducted an evaluation of a digital app (myAsthma Biologic, [mymhealth]). The study employed qualitative interviews with NHS staff (n=13) and patients (n=10) to assess usability, patient experience, and administrative burden in 3 SACs. Additionally, quantitative engagement data from the app and usability metrics were analysed. Pathway mapping informed semi-structured interview discussion guides. <bold>Results:</bold> ~2,800 users have been registered on the app in 11 SAC’s. Preliminary findings indicate broad acceptance and usability. NHS staff reported reduced administrative burden in patient monitoring and data entry. Patients found the app intuitive and useful for self-management. However, digital literacy gaps, integration challenges, and the need for long-term outcome validation were noted. Further quantitative analysis is ongoing. <bold>Conclusion:</bold> The app demonstrates potential in enhancing severe asthma care by supporting self-management and improving data collection efficiency. However, inequities in access to digital tools and specialist care persist. Addressing these barriers and leveraging disruptive technologies will be key to realising the full potential of apps in the NHS.