Dermoscopy in the diagnosis of cutaneous B-cell lymphomas

The diagnosis of cutaneous B-cell lymphomas is a challenging clinical task due to nonspecific nature of the skin manifestations in this disease. Since 2015, dermatoscopy has been used as an additional research method for the diagnosis of cutaneous B-cell lymphomas. Dermatoscopy is an inexpensive, non-invasive, and painless diagnostic method that allows to quickly obtain additional information about the disease. Currently known dermatoscopic signs, taking into account clinical and history data, may suggest a diagnosis of cutaneous B-cell lymphoma. The article clearly demonstrates the possibilities of dermatoscopy in the diagnosis of cutaneous B-cell lymphomas. However, dermatoscopy cannot replace the pathomorphological and immunohistochemical study of a skin biopsy which is the “golden standard” required for the diagnosis of cutaneous B-cell lymphoma. In some cases, a molecular genetic screening is performed to determine B-cell clonality in primary marginal zone cutaneous lymphomas with a pronounced T-cell component.