Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences

20250 citationsJournal Articlegold Open Access

Authors

Michelle Binod · University of California, Los Angeles

Lin Chang · University of California, Los Angeles

Ming Wei Hung · University of California, Los Angeles

Tien S. Dong · University of California, Los Angeles

Lisa A. Kilpatrick · University of California, Los Angeles

Anthony Tomasevic · University of California, Los Angeles

Michelle Choy

Abstract

Our findings highlight the unique microbiota and brain networks contributing to a complex interplay of chronic stress as measured by early life adversity, the brain-gut-microbiome system, and IBS pathophysiology which can inform therapeutic targets aimed at mitigating the long-term impacts of early life stress in female IBS patients.

Topics & Keywords

Gut microbiota and health Gastrointestinal motility and disorders Tryptophan and brain disorders

Publication Details

Published in: Biology of Sex Differences

Volume 16, Issue 1, pp. 101-101

DOI: 10.1186/s13293-025-00757-w

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Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences

Authors

Abstract

Topics & Keywords

Publication Details