GrafGen: distance-based inference of population ancestry for Helicobacter pylori genomes

GrafGen provides a reliable approach for classifying H. pylori ancestry and correcting for bacterial population stratification in GWAS. By enabling more accurate inference of genotype-phenotype associations, the method enhances studies of bacterial genetics and host-pathogen interactions. The underlying algorithm is extensible to other haploid organisms with adequate reference data, broadening its relevance beyond H. pylori.