Silver multilayer coating on orthopedic implant material of different alloys and surfaces significantly reduces bacterial colonization

These findings demonstrate a thorough and broad-spectrum antibacterial activity of the SML coating across diverse implant materials and surface textures. Future studies will focus on testing clinical PJI isolates in both <i>in vitro</i> and <i>in vivo models</i> to further evaluate the translational potential of the SML coating for prevention of bacterial colonization in joint arthroplasty.