Monte Carlo simulations of geometric deformation of Harrison–Anderson–Mick applicators used in intraoperative radiation therapy

This study quantified the changes in dose due to material and geometric differences that are currently not accounted for by the TPS. While not accounting for the material of the applicator contributes to negligibly, the presence of backscattering material can contribute up to 5%. The radius of the bending of the applicator was found to potentially have the largest impact on the dosimetry of the central plane, with deviations up to 25%.