25P Genomic ground truth for AI-based image classification of CELLSEARCH® circulating multiple myeloma cells

The CELLSEARCH® CMMC assay is a peripheral blood-based test for Research Use Only (RUO) to enumerate plasma cells and circulating multiple myeloma cells (CMMCs) in patients with Multiple Myeloma (MM) and its precursor stages. Elevated CMMC counts are associated with poor clinical outcome in MM (Foulk et al., 2017), while their molecular characterization could support the identification of treatment targets and mechanisms of resistance. In the CELLSEARCH workflow, CMMCs are defined as CD138+/CD38+/DAPI+/CD45-/CD19- and are currently selected manually by operators, a process that is time-consuming and potentially subjected to interpretations.