Molecular Resonance Quantification and Label‐Free Interactome Characterization of Total Proteome of Tumor Specimens Decipher Responder and Success Predictors in Colorectal Cancer Patients Treated With Panitumumab

This study presents an integrative molecular profiling strategy that combines PIMS, NPOT, and proteomics to uncover mechanistically relevant biomarkers of therapeutic response in colorectal cancer. By identifying an EGFR-centered interactome and responder-specific protein signatures, the research offers a novel approach to stratify panitumumab response and supports advancement of precision oncology in clinical settings.