Characterization of a factor VIII/immunoglobulin heavy chain μ double-knockout mouse model of hemophilia A for long-term exposure to factor VIII proteins

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Authors

Lara Monica · Medizinische Hochschule Hannover

Olga Oleshko · Medizinische Hochschule Hannover

Luísa Aires · Octapharma (Switzerland)

Silvio Wuschko · Octapharma (Austria)

Jonas Füner

Helmut Paul · Octapharma (Austria)

Patrick Schauerte

D L Jespersen

Abstract

The DKO mouse model can be used for long-term studies of FVIII products and other hemostatic proteins, enabling the evaluation of repeated-dose PK and prophylactic efficacy without interference from inhibitor formation.

Topics & Keywords

Hemophilia Treatment and Research Blood properties and coagulation Protein purification and stability

Publication Details

Published in: Research and Practice in Thrombosis and Haemostasis

Volume 10, Issue 1, pp. 103277-103277

DOI: 10.1016/j.rpth.2025.103277

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Characterization of a factor VIII/immunoglobulin heavy chain μ double-knockout mouse model of hemophilia A for long-term exposure to factor VIII proteins

Authors

Abstract

Topics & Keywords

Publication Details