Study of the relationship between Botox and skin repair in laboratory rats

Botulinum toxin is a polypeptide chain consisting of a heavy chain (100 kDa) and a light chain (50 kDa). Botox consists of (7) types of neurotoxins, however only toxins A and B are used clinically. The current study was conducted on (18) samples of female laboratory rats divided into 3groups, with 6 rats per group, where they were injected with different concentrations of Botox. These groups include: Group A, which is the control group, Group D, which was injected with a concentration of 0.1, and Group E, which was injected with a concentration of 0.05. The skin thickness was measured. The results of the statistical analysis showed a significant decrease (p≤0.05) in the average thickness of the skin layers. Botox injections affect the thickness of the skin layers without being affected by the injection dose.