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In the dental field, the value of early prevention is self-evident. Appropriate use of fluoride, parental and child education on correct oral hygiene practices, early detection of conditions such as molar-incisor hypomineralisation, implementation of pit and fissure sealing programmes, and dietary management aimed at reducing sugar intake are all interventions that demonstrate long-term benefits. These measures not only improve the prognosis of future treatments, but also reduce susceptibility to oral diseases in adulthood as well as systemic disorders. Dental caries, the most prevalent chronic disease worldwide, continues to increase in both primary and permanent dentition. Its early occurrence is not merely a dental problem, but also an indicator of exposure to unhealthy lifestyles and to risk factors common to other major conditions, such as obesity, diabetes, and cardiovascular disease. This highlights oral prevention as a cornerstone of broader non-communicable disease prevention strategies, in line with WHO recommendations. Examples from daily practice clearly show that paediatric dental prevention is not a cost, but a lifelong investment: every early intervention generates benefits that persist for decades. The challenge in the coming years will be to increasingly integrate oral prevention into maternal and child health programmes, schools, and public health policies, building concrete bridges with paediatrics, nutrition, and other health disciplines, extending through to geriatrics. On the occasion of this anniversary, this special issue seeks to reaffirm a key message: paediatric dental prevention is fundamental to securing oral health and general well-being across the life-course, from childhood to old age. This statement is not a rhetorical claim, but a commitment firmly grounded in scientific evidence.