Anchor-based evaluation of digital motor biomarkers from a 2-year observation in 100 patients with multiple sclerosis

Our findings yield a well-applicable set of DMO that may support definitions of disability accumulation in (early) pwMS. Establishing patient relevance remains challenging due to expectedly low clinical progression rates. The distinct patterns captured by EDSS and MSWS-12 definitions underline the need for multiple anchors when validating new biomarkers. Trial registration ClinicalTrials.gov, NCT04993274, 2021-03-09 retrospectively registered.