What is the role of the IgE-mediated allergy in severe asthma?

IgE-mediated pathways play central role in the pathogenesis of various allergic diseases, including asthma. However, the allergic burden seems to be more important in children with SA than in adults. Future research may provide a better understanding of the role of IgE-mediated allergy in SA and coexisting allergic diseases with improvement in their clinical outcomes.