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Abstract INTRODUCTION: While TKIs significantly extend survival in CML, their adverse events (AEs) may lead to treatment discontinuation and poor health-related quality of life (HRQoL). Few studies have described the HRQoL of US patients (pts) on TKIs. This study assessed the humanistic burden of pts with CML treated with first-line (1L) TKIs, including their AE profile, HRQoL, and work productivity, using patient-reported outcomes. We also evaluated communication barriers between pts and treating physicians. METHODS: Cross-sectional online surveys were conducted (June-December 2024) among US CML pts. Adults receiving 1L TKIs (imatinib, dasatinib, nilotinib, bosutinib) for ≥3 months (mos) were eligible to participate; asciminib in 1L was not yet approved at study start. AE data were collected via PRO-CTCAE, and pts completed surveys on patient-physician communication about AEs. HRQoL was evaluated using the PROMIS-Global Health-10 (Global Physical Health [GPH] and Global Mental Health [GMH], general population mean±SD of 50±10, lower T-scores=poorer health), and Work Productivity and Activity Impairment: Specific Health Problem (WPAI:SHP, higher percentages=greater impairment) questionnaires. “Low points,” defined as the time(s) when AEs had the greatest impact on HRQoL, were also reported. RESULTS: A cohort of 162 pts (median age 45 yrs [range 18-82], 60% female, 19% non-White) treated with a 1L TKI (42% imatinib, 38% dasatinib, 11% nilotinib, 9% bosutinib) participated. Half were employed (51%; 21% retired, 15% not employed, 6% on disability) and treated in a community-based setting (54%; 41% academic, 5% other/unsure). Two-thirds were commercially insured (65%; 26% Medicare, 7% Medicaid, 2% military/unsure). Over half had been on 1L TKI for ≥1 yr (59%; 11% 3 to <6 mos, 30% 6 mos to <1 yr). In the last 7 days, pts reported a median of 3 AEs (range 0-14); most commonly, fatigue (51%), pain (45%; joint/muscle pain), and gastrointestinal (33%; nausea, diarrhea, vomiting, constipation). Three-quarters (75%) had ≥1 AE, mostly chronic, in the last 7 days. Most pts (82%) experienced low points since TKI start, most commonly in the first 3 mos of treatment (59%), with 24% reporting ≥1 low point in the last 7 days. Nearly all pts (98%) reported discussing AEs at least once with their physician, most frequently at diagnosis (72%) or at subsequent visits (75%); half (54%) discussed AEs at every visit. Two-thirds (64%) reported being satisfied with their discussions about AEs. However, some delayed or did not report AEs to their physicians (17%), for reasons that they “just had to live with it” (70%), were “afraid the doctor may decide to change treatment” (44%), or did not want to “be a burden” (33%). PROMIS-GH-10 revealed pts with CML had worse health than the general population, with mean±SD GPH T-score of 43.2±7.4 and GMH T-score of 43.9±7.6. Among pts with low points in the last 7 days, GPH and GMH T-scores were even worse (GPH: 37.5±6.5; GMH: 38.0±7.4). WPAI SHP showed over half (54%) of pts reported employment change due to CML (12% retired early, 11% from full- to part-time, 10% from full-time to unemployed, 8% stopped working temporarily or reduced workload), with an overall mean activity impairment of 35.1% (range 0-100%). Among those employed, 80% reported work impairment due to CML, with a mean percent work productivity loss of 29.9%. Mean impairment while working (presenteeism) and work time missed (absenteeism) due to CML were 27.2% and 7.6%, respectively. Pts with low points in the last 7 days had even higher mean activity impairment (52.8%) and work productivity loss (38.8%) due to CML. CONCLUSIONS:Our real-world study demonstrates pts with CML treated with 1L TKIs in the US experience chronic AEs contributing to worse HRQoL, including physical and mental health, as well as work impairment. This finding of impaired work productivity due to CML is particularly significant in the context of employer-provided health insurance in the US. While most patients discussed AEs with physicians early in their disease course, only half discussed AEs at every visit and two-thirds were satisfied with their discussions. In addition, some patients delayed or avoided reporting AEs due to internal barriers. As CML requires lifelong treatment, pts may benefit from greater recognition of AEs and strategies to improve HRQoL and maintain work productivity, including TKIs with better tolerability and more consistent approaches to monitoring.